Oxidative stress response (WP408)

发布时间：2025-08-22 20:26

Homo sapiens

Oxidative stress represents an imbalance between the production and manifestation of reactive oxygen species and a biological system’s ability to readily detoxify the reactive intermediates or to repair the resulting damage. Disturbances in the normal redox state of tissues can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipids, and DNA. Some reactive oxidative species can even act as messengers through a phenomenon called redox signaling. In humans, oxidative stress is involved in many diseases. Examples include sickle cell disease,[1] atherosclerosis, Parkinson’s disease, heart failure, myocardial infarction, Alzheimer’s disease, schizophrenia, bipolar disorder, fragile X syndrome[2] and chronic fatigue syndrome, but short-term oxidative stress may also be important in prevention of aging by induction of a process named mitohormesis.[3] Reactive oxygen species can be beneficial, as they are used by the immune system as a way to attack and kill pathogens. Source: Wikipedia Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Niradiz Reyes , Kristina Hanspers , Ismael Reyes , KHALID RASHID , Alex Pico , Martijn Van Iersel , Egon Willighagen , Xuyongdeng , Harald Schmidt , and Eric Weitz

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Cited In

Early transcriptional responses of bronchial epithelial cells to whole cigarette smoke mirror those of in-vivo exposed human bronchial mucosa (2022). Selenotranscriptome Network in Non-alcoholic Fatty Liver Disease (2021). Investigating the Molecular Processes behind the Cell-Specific Toxicity Response to Titanium Dioxide Nanobelts (2021). Heterogeneity of Lipid and Protein Cartilage Profiles Associated with Human Osteoarthritis with or without Type 2 Diabetes Mellitus (2021). Induced pluripotent stem cell–based mapping of β-globin expression throughout human erythropoietic development (2018). Transcriptional Analysis of T Cells Resident in Human Skin (2016). MicroRNAs as potential biomarkers for doxorubicin-induced cardiotoxicity. Single-cell profiling unveils a geroprotective role of Procyanidin C1 in hematopoietic immune system via senolytic and senomorphic effects (2025). The impact of PPARα activation on whole genome gene expression in human precision cut liver slices (2015).

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Organisms

Homo sapiens

Communities

ONTOX

Annotations

Pathway Ontology

oxidative stress response pathway

Label Type Compact URI Comment Reactive oxygen species Metabolite chebi:26523 MGST1 GeneProduct ncbigene:4257 SP1 GeneProduct ncbigene:6667 SOD2 GeneProduct ncbigene:6648 NFKB1 GeneProduct ncbigene:4790